In 2012, under the supervision of both INSERM and the University Paris Descartes, the Center of Psychiatry and Neuroscience (INSERM U894) will settle in Saint Anne hospital. With 5,000 m2 of space, the building will accommodate teams dedicated to both basic and paraclinical research with the aim of strengthening and cultivating links between the psychiatric and neuroscience departments of the hospital.

Schematic view of project

The Center will also provide young, promising teams, invited professors and industry partners with about 400 m2 of laboratory space.

In addition, the Center will be equipped with 550 m2 of space teaching activities.
The Center will also maintain strong interactions with the Research and Clinical Evaluation Department, which oversees clinical protocols, particularly those involving the detection of endophenotypes of psychiatric diseases and those that evaluate the therapeutic effects of the psychotropic compounds.


 View of building under renovation

The decision to create a research center within Saint Anne hospital results from the strategic goal of integrating basic and clinical research in psychiatry and neuroscience.
The Center bridges the gap between basic and clinical research in a setting which has historical roots in understanding psychiatric and neurological problems via researching the central nervous system.

The operating result of this strategy is a broad frame of activities performed by the Center’s teams and advanced technical platforms. By sharing thematic and methodological actions, the center optimizes the use of the technical, human and financial resources implemented by the partner institutes INSERM, University Paris Descartes, and other regional hospitals with welfare services.
Together the Center’s resources provide an innovative setting that facilitates the discovery of scientific and medical breakthroughs in fields of psychiatry, neurology, and neuroscience.


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After being evaluated by the Agency for the Evaluation of Research and Higher Education (a.k.a. “AERES”), the Center obtained the label UMR_S* for 4 years.

*The Mixed Unit of Research (UMR) is a laboratory having obtained a mixed label after it was evaluated by both the Ministry of Health and the Search (MESR) and a great research institute (CNRS, INSERM, INRA…). A UMR labeled by MESR and CNRS will be called UMR_C or UMR, by MESR and INSERM it will be UMR_S and if it is by MESR and INRA it iwill be UMR_A. UMR are also often called “associated laboratories”.


Research units from the Paul Broca Center, three teams from INSERM U288 (located at Salpétrière Hospital) and to 2 clinical teams from Saint-Anne Hospital combine to form the Center of Psychiatry and Neurosciences (CPN).

The CPN is under the supervision of INSERM and is affiliated with University Paris Descartes.


The Avenir team managed by Christian Neri became research unit 857 : Biology and neuron pathology .

Unit 752 leaves the Collège de France to join the Paul Broca Center. This unit works on "neuroglial plasticity" and was managed by Hervé Chneiweiss.


EMI 117 became a research unit 796. It was managed by Marie-Odile Krebs from 2006 to 2008.
The research topics was: Plasticity and psychiatric troubles.


An Avenir team (emergent team) joined the Center. Its theme was "Neuronal biology and physiophatology" and it was managed by Christian Neri from 2003 to 2007.


Units 159 and 109 were closed when their managers retired. Their coworkers continued with the creation of units 549 and 573. At the same time, a mixed INSERM team (EMI) joins the Center.

UR549 : Neurobiology of growth and aging. This unit was managed by Jacques Epelbaum from 2001 to 2006.

UR573: Neurobiology and Molecular Pharmacology. This unit was managed by Pierre Sokoloff from 2002 to 2004, then by Jean-Michel Arrang from 2004 to 2008.

EMI117: Physiopathology of schizophrenia. This EMI was managed by Marie-Odile Krebs from 2001 to 2006.


Two units were created in the Center.

UR159 : Neuroendocrinology. This unit was managed by Claude Kordon. In 1993 the theme of research became Dynamic of neuroendocrine systems.

UR161: Physiopharmacology of the nervous system. This unit was managed by Jean-Marie Besson.


Unit 111 joins the Paul Broca Center. Its research topic was "Neuropsychology and neurolinguistic".

It was managed by Henri Hecaen from 1972 to 1981, then by Pierre Rondot from 1982 to 1986.


Unit 110 joins Paul Broca Center.

This unit was managed by Raymond Sadoun and it investigated the Epidemiology on mental troubles.


From 1970 the first units moved into the Paul Broca Center.

UR 97: Neurophysiopathology and therapeutics of the epilepsies. This unit was managed by Jean Talairach from 1970 to 1973, by Jean Bancaud from 1974 to 1987, and then by Michel Lamarche from 1988 to 1995.

UR 109:Neurobiology. This unit was managed by Jean-Charles Schwartz. In 1986, the theme research was modified to become Neurobiology and Pharmacology.

The division of psychiatry was reorganized into sectors in order to move places of treatment closer to patients with the creation of outside centers, health centers, post-treatment homes, day and night hospitals, week hospitals, and therapeutic apartments.

The neurology department was settled in 1974. With tomograph, scanner, magnetic resonance imaging, neuroradiology it became a leading-edge discipline at St-Anne which allowed for the development of therapeutic radiology.


In 1952, psychiatry made spectacular headway at Saint-Anne with the application of the first neuroleptics whose action will later revolutionize therapeutics worldwide.

At the same time, neurosurgical practices develop with new research and intervention methods, which has led to the stereotaxic neurosurgery practiced today. Neurosurgery of the pain also became very important for the hospital.


In 1947, the section of bio-psychopathology of the child is created It intends to give to the unsuitable childhood and the families a clinical and therapeutic original set in its double emotional and cognitive aspect.


In 1941, one of the first French laboratories of electroencephalography was established at Ste-Anne hospital.


In 1922, Edouard Toulouse created the “mental prophylaxis center” which was the first department in which patients were able to go free without being interned by the law of June 30, 1838.


In 1863, Napoleon III commissioned the creation of a psychiatric hospital in Paris at the location of Saint-Anne farm. This hospital is named a “clinical asylum” because it was intended to become a place of treatment, research and teaching related to mental illnesses. Haussmann, the prefect in Paris, oversaw the project. The asylum was inaugurated on January 1, 1867 and the first patient was accepted on May 1 of the same year.

Over the years Saint-Anne has provided for the protection of the mentally ill with the limited therapeutic means that were available in this period. Important and in-depth medical research is developed.