Post-doctoral position in neuroscience with focus on stroke pathophysiology and therapy

A full-time post-doctoral position is open at the INSERM/Paris-Descartes University Centre for Psychiatry and Neurosciences (CPN) (http://cpn.paris5.inserm.fr). Situated within the Sainte-Anne Hospital Campus in Paris’ 14th arrondissement, the CPN is one of the leading centers in translational neuroscience and neurovascular research in France, hosting several prominent research groups. The center has state-of-the-art technology platforms as well as international environment with students and fellows from around the world. The Stroke Research group (director: Prof Jean-Louis Mas) carries out both clinical and pre-clinical translational research and has expertise in the pathophysiology and therapy of acute brain ischemia. The available position is in Prof Jean-Claude BARON’s laboratory. The CPN will move into a 4300 m2 brand new building in the fall of 2016, also on the Sainte-Anne campus. Sainte-Anne hospital is the only hospital exclusively devoted to brain diseases in the Paris area.

One great challenge in acute stroke therapy is the narrow time window, counted in hours, within which therapeutic interventions can be effective. In addition, many patients may be ineligible or may not respond to thrombolysis, an intravenous treatment whose aim is to dissolve the blood clot blocking the artery and causing the symptoms, or to thombectomy (mechanical removal of the clot via endovascular approaches). Furthermore, removing the clot can not revert established brain damage. There is therefore a need to develop additional treatment options replacing, or complementing available reperfusion therapies. An exciting new possibility is sensory stimulation (SS). In this non-pharmacological approach, SS is delivered onto the affected body side. This simple approach has been shown in numerous rodent studies to markedly reduce brain infarct volume following middle cerebral artery (MCA) occlusion, although other studies showed less clear effects. This benefit is believed to derive from enhanced perfusion to the ischemic but still viable brain tissue, thanks to residual vasodilatory capacity from partly preserved neurovascular coupling despite ongoing MCA occlusion. Interestingly, some studies suggest that SS may be effective in the early stages of ischemia, but detrimental if administered at later time-points. The project in which the post-doctoral scientist will be involved aims to further investigate this exciting new therapeutic approach using various protocols and cutting edge techniques. The laboratory is part of an international trans-Atlantic consortium made of seven independent laboratories with expertise in basic neurophysiology and experimental stroke. The appointee will have close interaction with the members of these laboratories. For more information, please see: https://www.fondationleducq.org/transatlantic-networks-of-excellence/funded-networks/

Relevant recent publications from the laboratory:
1.    Hughes JL et al: Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat. NeuroImage, 2010, 49: 19–31.
2.    Ejaz S et al. Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study. Neurobiol. Dis., 2013, 51: 120–32.
3.    Emmrich JV et al. Quantitative vs semi-quantitative whole-brain assessment of regional selective neuronal loss and microglial activation in a rodent model of transient focal ischaemia. J. Cereb. Blood Flow Metab., 2015, 35: 20-27.
4.    Ejaz S et al. Cortical selective neuronal loss, impaired behaviour and normal MRI in a new rat model of true transient ischemic attacks. Stroke, 2015, 46: 1084-92.
5.    Brunner C et al. Mapping the dynamics of brain perfusion during and following transient middle cerebral artery occlusion in a rat model using functional ultrasound (fUS). J. Cereb. Blood Flow Metab. 2015 Dec 31. pii: 0271678X15622466. [Epub ahead of print]
6.    Ejaz S et al. Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits after brief focal ischemia in the rat. Brain 2016 Jan 14. pii: awv391. [Epub ahead of print].

Offered position:
Post-doctoral position (funded by a grant from the Leducq Foundation)

Candidate profile
A highly motivated candidate with PhD and/or MD degree is sought with strong experience in neuroscience and neurovascular biology, including in mouse/rat handling and anesthesia, and in stroke surgery (transient and permanent MCA occlusion using filament, microclip…). Preference will be given to candidates with a demonstrated track record applying a translational approach to study stroke mechanisms. Experience in techniques such as behavioral assessment, histopathology, neuroimaging, optogenetics and confocal microscopy is an advantage. Good knowledge of basic statistical tests and packages is also highly valued. An excellent track record of original publications in international peer-reviewed journals, independence and ability to conceive, critique and communicate results and work in a team will all be valued as well. International candidates are encouraged to apply. Please send a motivation letter and a brief CV (4 pages maximum).

Paris 14, INSERM U894, Hôpital Sainte-Anne, France

Annual salary: c. €26,500 (net)

Application deadline

Jean-Claude Baron


Le laboratoire Mémoire et Cognition souhaite s’agrandir avec des chercheurs et enseignants-chercheurs

Le laboratoire Mémoire et Cognition, Université Paris Descartes, récemment labellisé équipe Inserm dans le Centre de Psychiatrie et Neurosciences (Inserm U894), développe ses recherches sur la mémoire en lien avec la cognition (identité, contrôle exécutif, émotion, perception/action) dans le domaine fondamental et clinique, de l’enfant à la personne âgée, chez les sujets sains et les patients en neurologie et psychiatrie. Il bénéficie d'une excellente assise (académique et clinique) et de plateformes techniques diverses (réalité virtuelle, RED, IRM, EEG, TMS...) qui lui permettent de développer des projets dans une approche multimodale de la cognition incarnée.

Ce laboratoire souhaite s’agrandir avec des chercheurs et enseignants-chercheurs très motivés et dynamiques, désireux de développer des travaux innovants et ambitieux dans le domaine fondamental et de la santé.

Si vous êtes intéressé(e), contacter P. Piolino, pascale.piolino@parisdescartes.fr



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